CNS Drugs. Dec;30(12) Neurological and Neuropsychiatric Adverse Effects of Dermatologic Medications. Liu M(1), Huang YY(1), Hsu S(2). Here, the possible effects of latent toxoplasmosis on neurological and psychiatric disorders are surveyed and some general methodological. Some neurological and neuropsychiatric adverse effects associated with these medications are serious enough that the US FDA requires.
and neurospychiatric effects Neurological
For patients too, specialist clinics and expert advice have become crucial for their ongoing care. But it is also worth considering the possibility that hyper-specialism comes at a potential cost: Take depression or fatigue, two common and important symptoms that frequently occur in many neurological disorders. Surely these disorders have very different underlying molecular pathologies, so there cannot be a common, mechanistic explanation across diseases?
The answer though might not be at the level of molecular pathology. Both diseases are associated with disruption to brain systems and it is entirely possible that, regardless of the underlying pathology, the symptoms in any patient with either diagnosis arise because of the constellation of brain systems that are disrupted.
Might there be common brain systems that are disrupted across diseases to lead to similar symptoms or phenotypes? Intriguingly, very similar ideas have gained impetus in psychiatry where the attachment to diagnostic label is perhaps less strong, at least for some people. The lack of clearly established molecular signatures for the majority of psychiatric conditions means that there is growing concern that traditional disease categories might not capture underlying biology well.
The ultimate aspiration might be to map disrupted brain function to specific brain circuits or networks, across conventional diagnostic boundaries. In turn, this might lead to treatments aimed at the disrupted function or network, regardless of the surface diagnostic label attached to a particular patient. To make this more concrete, consider the negative symptoms that occur in some people with schizophrenia. Very similar symptoms of loss of motivation or anhedonia might occur in some individuals with major depressive disorder.
Is it possible that both could be treated in the same manner? Perhaps, although it would be important first to ensure that seemingly similar symptoms of loss of motivation are actually manifestations of disruption to the same underlying brain system Whitton et al. Indeed, maybe these markers tempt us away from some important issues which, if addressed head on, might actually make an important impact on the management of patients, across different brain diseases.
Take, for example, the case of neurodegenerative conditions. For many people, finding cures for these diseases means discovering treatments for the cognitive deficits associated with them: However, such a view risks ignoring the profound behavioural changes that often accompany and have such a major impact on quality of life in patients with these conditions Wint and Cummings, A wide range of neuropsychiatric symptoms are now recognized to be associated with neurodegenerative disorders, with many patients suffering from more than one of these during the course of their illness.
The symptoms vary from agitation, irritability and impulsivity through to apathy and indifference, from depression to euphoria, from delusions and hallucinations to anxiety and sleep disturbance, from loss of empathy and socially inappropriate behaviour through to changes in eating behaviour and stereotyped behaviours such as pacing, wandering and rummaging.
These neuropsychiatric changes cut across diseases. Unsurprisingly, delusions and disruptive behaviours such as aggression appear to be the most burdensome to caregivers Rocca et al. Is it possible that disruption of common brain systems might lead to the same neuropsychiatric symptom across neurodegenerative diseases?
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Neurological and Neuropsychiatric Adverse Effects of Dermatologic Medications.
Neurological disorders all involve malfunction of or damage to the nervous system. The hallmarks of psychiatric disorders, on the other hand. A review of systemic medications for dermatologic diseases describes a wide range of adverse events, which range from mild and reversible to. Neurological syndromes which can be mistaken for psychiatric conditions. Free consequences (such as depression and anxiety) of much physical disease.